![]() During mechanical ventilation, secretions contaminated with oropharyngeal pathogens pool in the subglottic region (tracheal region between the ETT cuff and the vocal cords) and enter the lower airways via microaspiration. However, up to now, a ‘magic number’ for the optimal sealing of the trachea is not available yet. Conversely, suboptimal tracheal sealing, usually associated with P cuff values below 20 cmH20, may result in significant fluid leakage around the cuff, which is a crucial risk factor for ventilator associated pneumonia (VAP). Overinflation of the ETT cuff may compromise capillary perfusion causing ischemic tracheal wall damage, ulcerations and tracheal stenosis. Maintaining the endotracheal tube (ETT) cuff appropriately inflated plays a crucial role in the management of intubated patients. The funders contributed to the study design and data analysis but they did not have any role in data collection, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. ![]() ![]() This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: The study was sponsored by Hospitech Respiration LTD (Petach-Tikva, Israel). Received: DecemAccepted: MaPublished: May 11, 2017Ĭopyright: © 2017 De Pascale et al. PLoS ONE 12(5):Įditor: Ritesh Agarwal, Postgraduate Institute of Medical Education and Research, INDIA (2017) CO 2 driven endotracheal tube cuff control in critically ill patients: A randomized controlled study. Citation: De Pascale G, Pennisi MA, Vallecoccia MS, Bello G, Maviglia R, Montini L, et al.
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